During the early 1970's while Brånemark was deep into his research into osseointegration, other Europeans followed suit. They included André Schröeder at Switzerland's Berne University who was working on a similar implant for clinical application in conjunction with the renowned Straumann Institute.
Long-term follow-up study of osseointegrated implants in the treatment of totally edentulous jaws.Adell R, Eriksson B, Lekholm U, Brånemark Pl, Jemt T. Int J Oral Maxillofac Implants 1990 Winter;5(4):347-59. PMID: 2094653
1982 was a huge turning point for Brånemark and it was a point that he had been working towards for the past 17 years. This included 15 years of clinical follow-up trials. Yet despite the hugely positive results, he was reluctant to present his findings to the public at the Toronto conference, because he felt quite simply, that the world still wasn't ready for dental implants.
A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Adell R, Lekholm U, Rockler B, Brånemark PI. Int J Oral Surg. 1981 Dec;10(6):387-416. PMID: 6809663
Anyone who knows anything about dental implants is aware of the story of Per-Ingvar Brånemark and how he accidentally discovered the process he later named as osseointegration. You're probably also aware that despite him being named as one of the most influential people in the dental profession, he wasn't actually a dentist.
Osseointegration and its experimental background., Brånemark PI., J Prosthet Dent. 1983 Sep;50(3):399-410. PMID: 6352924
To put it another way.... out of 418 clinical papers, 262 of them were deemed serious enough to have led to misleading conclusions!
Statistical methodology in oral and dental research: pitfalls and recommendations. Hannigan A, Lynch CD.
In 2014 a 34-year analysis study on the influences that affect early dental implant failure in patients came to an end. It happens to be one of the largest observational studies of its kind anywhere in the world.
Factors Influencing Early Dental Implant Failures. B.R. Chrcanovic, J. Kisch, T. Albrektsson, and A. Wennerberg.